IL20RA Antikörper (AA 1-200)

Produktnummer ABIN7868584

Der Maus Monoklonal anti-IL20RA Antikörper (Klon IL20RA-1752) (ABIN7868584) detektiert spezifisch IL20RA in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IL20RA Antikörper (AA 1-200) (ABIN7868584)

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL20RA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: IL20RA-1752

Produktdetails anti-IL20RA Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: IL20R alpha Antibody / IL-20 receptor subunit alpha (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL20R alpha antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IL20R alpha antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the IL20R alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu IL20RA

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Andere Bezeichnung: IL20R alpha

Hintergrund: The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-l. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ra and IL-20Rb. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ra and IL-20Rb all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

UniProt: Q9UHF4