Rekombinanter GLUL Antikörper (AA 1-200)

Produktnummer ABIN7868505

Der Maus Monoklonal anti-GLUL Antikörper wird verwendet zum Nachweis von GLUL in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter GLUL Antikörper (AA 1-200) (ABIN7868505)

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GLUL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RGLUL-8620

Produktdetails anti-GLUL Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Recombinant GLUL Antibody / Glutamine Synthetase

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the recombinant GLUL antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant GLUL antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant GLUL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GLUL

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Andere Bezeichnung: GLUL

Hintergrund: Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

UniProt: P15104

Pathways: Positive Regulation of Peptide Hormone Secretion