VPRBP Antikörper (AA 1-195)

Produktnummer ABIN7868350

Der Kaninchen Polyklonal anti-VPRBP Antikörper (ABIN7868350) detektiert spezifisch VPRBP in ELISA, WB, FACS, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für VPRBP Antikörper (AA 1-195) (ABIN7868350)

Target: VPRBP (Vpr (HIV-1) Binding Protein (VPRBP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPRBP Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-VPRBP Antikörper

Bindungsspezifität: AA 1-195

Verwendungszweck: VPRBP Antibody / DCAF1

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-R195) was used as the immunogen for the VPRBP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the VPRBP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the VPRBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu VPRBP

Target: VPRBP (Vpr (HIV-1) Binding Protein (VPRBP))

Andere Bezeichnung: VPRBP

Substanzklasse: Viral Protein

Hintergrund: VprBP was first identified as a protein that can interact with HIV-1 viral protein R. It is a component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex that could interact with HIV-1 virus Vpr protein and HIV-2 virus Vpx protein. VprBP is a 1,507-amino acid protein that contains conserved domains, including YXXY repeats, the Lis homology motif, and WD40 repeats. Through binding to Vpr, VprBP allows Vpr to modulate the catalytic activity of the CUL4-DDB1 complex, which in turn leads to the induction of G2 phase arrest in the virus-infected cells. Recently it has been reported that VprBP is able to regulate the p53-induced transcription and apoptotic pathway.

UniProt: Q9Y4B6