MCEMP1 Antikörper (AA 1-183)

Produktnummer ABIN7868272

Der Kaninchen Polyklonal anti-MCEMP1 Antikörper (ABIN7868272) detektiert spezifisch MCEMP1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für MCEMP1 Antikörper (AA 1-183) (ABIN7868272)

Target: MCEMP1 (Mast Cell Expressed Membrane Protein 1 (MCEMP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCEMP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MCEMP1 Antikörper

Bindungsspezifität: AA 1-183

Verwendungszweck: MCEMP1 Antibody / Mast cell-expressed membrane protein 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human MCEMP1 recombinant protein (Position: M1-Q183) was used as the immunogen for the MCEMP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MCEMP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MCEMP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MCEMP1

Target: MCEMP1 (Mast Cell Expressed Membrane Protein 1 (MCEMP1))

Andere Bezeichnung: MCEMP1

Hintergrund: MCEMP1 antibody detects Mast cell-expressed membrane protein 1, a type I transmembrane protein implicated in immune cell activation and inflammatory signaling. The UniProt recommended name is Mast cell-expressed membrane protein 1 (MCEMP1). This protein is predominantly expressed in mast cells, monocytes, and macrophages, where it may function as a receptor or co-stimulatory molecule regulating immune responses.

Functionally, MCEMP1 antibody identifies a 177-amino-acid membrane glycoprotein featuring a short extracellular region, a single transmembrane domain, and a cytoplasmic tail containing an immunoreceptor tyrosine-based activation motif (ITAM). Upon phosphorylation, MCEMP1 can recruit SYK kinase and other signaling molecules, promoting cytokine production and cell activation.

The MCEMP1 gene is located on chromosome 19q13.4 and is expressed primarily in immune cells of the myeloid lineage, including mast cells, basophils, and macrophages. MCEMP1 expression increases during inflammation, allergic responses, and infection, suggesting a role in innate immune activation. It may also contribute to cytokine cross-talk between immune cells and epithelial barriers.

Pathologically, aberrant MCEMP1 expression is associated with allergic inflammation, asthma, and sepsis. Its upregulation in immune cells correlates with hyperinflammatory states, making it a potential biomarker for inflammatory disorders. Research using MCEMP1 antibody helps clarify its role in immune activation and signaling mechanisms.

MCEMP1 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect immune cell membrane proteins. NSJ Bioreagents provides MCEMP1 antibody reagents optimized for research in immunology, inflammation, and signal transduction.

Structurally, Mast cell-expressed membrane protein 1 contains a single-pass transmembrane segment and cytoplasmic ITAM motifs that drive downstream kinase signaling. This antibody aids in studies of MCEMP1's potential receptor functions and involvement in immune regulation.

UniProt: Q8IX19