PIN1 Antikörper (AA 1-163)

Produktnummer ABIN7868227

Der Maus Monoklonal anti-PIN1 Antikörper (Klon 5E5-) (ABIN7868227) detektiert spezifisch PIN1 in WB, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Affe.

Kurzübersicht für PIN1 Antikörper (AA 1-163) (ABIN7868227)

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reaktivität: Human, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 5E5-

Produktdetails anti-PIN1 Antikörper

Bindungsspezifität: AA 1-163

Verwendungszweck: PIN1 Antibody / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-E163) was used as the immunogen for the PIN1 antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PIN1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Andere Bezeichnung: PIN1

Hintergrund: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

UniProt: Q13526