C6orf130 Antikörper (AA 1-152)

Produktnummer ABIN7868195

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch C6orf130 in WB, ELISA, IHC, ICC, FACS und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für C6orf130 Antikörper (AA 1-152) (ABIN7868195)

Target: C6orf130 (OARD1) (O-Acyl-ADP-Ribose Deacylase 1 (OARD1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C6orf130 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-C6orf130 Antikörper

Bindungsspezifität: AA 1-152

Verwendungszweck: OARD1 Antibody / O-acetyl-ADP-ribose deacetylase 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human C6orf130/OARD1 recombinant protein (Position: M1-L152) was used as the immunogen for the OARD1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the OARD1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the OARD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu C6orf130

Target: C6orf130 (OARD1) (O-Acyl-ADP-Ribose Deacylase 1 (OARD1))

Andere Bezeichnung: OARD1

Hintergrund: OARD1 antibody detects ADP-ribose glycohydrolase OARD1, encoded by the OARD1 gene on chromosome 6q14.2. OARD1 antibody is used in research on ADP-ribosylation, DNA repair, and chromatin biology. OARD1 is an enzyme that removes ADP-ribose from proteins, acting as a mono-ADP-ribosylhydrolase. This activity counteracts PARP-mediated ADP-ribosylation, a key post-translational modification involved in DNA repair, transcription, and stress signaling.

Structurally, OARD1 is a ~17 kDa protein containing a macrodomain, which mediates binding and hydrolysis of ADP-ribose groups. The macrodomain recognizes ADP-ribosylated substrates and catalyzes removal of the modification. OARD1 localizes to the nucleus, where it associates with chromatin and DNA repair complexes. Isoforms generated by alternative splicing provide additional regulatory functions.

Functionally, OARD1 regulates chromatin dynamics and DNA repair by reversing mono-ADP-ribosylation on histones and DNA repair proteins. This counter-regulation maintains genomic stability and prevents accumulation of aberrant ADP-ribose modifications. Knockdown of OARD1 leads to DNA damage sensitivity, chromatin defects, and altered transcription. Researchers use OARD1 antibody to study ADP-ribosylation signaling, chromatin regulation, and DNA repair pathways.

Clinically, OARD1 has been implicated in cancer and neurodegeneration. Altered ADP-ribosylation dynamics contribute to oncogenesis by disrupting DNA repair and transcriptional regulation. OARD1 may also influence response to PARP inhibitors, which are used to treat BRCA-deficient tumors. Mutations or dysregulation of OARD1 have been linked to neurological disorders involving DNA damage accumulation. NSJ Bioreagents provides OARD1 antibody to support cancer, neurology, and epigenetics research.

Experimentally, OARD1 antibody is used in western blotting to detect the ~17 kDa protein, in immunohistochemistry to study nuclear expression, and in chromatin immunoprecipitation to examine ADP-ribosylation regulation. Co-immunoprecipitation with OARD1 antibody identifies partners including PARP family members and DNA repair proteins.

UniProt: Q9Y530