CEBPG Antikörper (AA 1-150)

Produktnummer ABIN7868182

Der Kaninchen Polyklonal anti-CEBPG Antikörper (ABIN7868182) detektiert spezifisch CEBPG in WB, ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für CEBPG Antikörper (AA 1-150) (ABIN7868182)

Target: CEBPG (CCAAT/enhancer Binding Protein (C/EBP), gamma (CEBPG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEBPG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-CEBPG Antikörper

Bindungsspezifität: AA 1-150

Verwendungszweck: CEBPG Antibody / CCAAT/enhancer-binding protein gamma

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human CEBPG recombinant protein (Position: M1-Q150) was used as the immunogen for the CEBPG antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CEBPG antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the CEBPG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CEBPG

Target: CEBPG (CCAAT/enhancer Binding Protein (C/EBP), gamma (CEBPG))

Andere Bezeichnung: CEBPG

Hintergrund: CEBPG antibody targets CCAAT/enhancer-binding protein gamma, a member of the CEBP family of transcription factors that regulate genes involved in immune response, metabolism, and cell differentiation. CEBPG lacks a canonical transactivation domain and instead acts as a dimerization partner for other CEBP family members such as CEBPA, CEBPB, and CEBPD, influencing transcription through heterodimer formation. This modulatory activity enables CEBPG to fine-tune expression of genes associated with inflammation, DNA repair, and oxidative stress responses. The protein is localized primarily in the nucleus, where it binds to CCAAT motifs within promoter regions and modulates transcriptional outcomes depending on its dimerization partner.

CEBPG is encoded by the CEBPG gene located on chromosome 19q13.11 and produces a protein of approximately 15 kilodaltons. It is ubiquitously expressed but particularly abundant in immune cells, liver, and lung tissues. Through interaction with CEBPB, CEBPG contributes to the regulation of cytokine expression, lipid metabolism, and acute phase responses. In addition to its transcriptional role, CEBPG has been linked to DNA damage tolerance pathways, where it may cooperate with ATF4 to activate antioxidant genes during cellular stress. The CEBPG antibody is therefore widely used in studies of transcriptional regulation, inflammation, and stress response signaling.

Research indicates that CEBPG participates in regulatory networks controlling macrophage activation and epithelial defense responses. Overexpression or silencing of CEBPG affects the expression of downstream effectors such as SOD2, GPX1, and TNF, linking this factor to redox balance and inflammatory signaling. Because of its cooperative interactions with other CEBP proteins, CEBPG serves as an important hub in transcriptional cascades influencing differentiation and immune adaptation. The CEBPG antibody is validated for western blotting, immunofluorescence, and chromatin immunoprecipitation assays, enabling analysis of protein expression and DNA-binding activity. NSJ Bioreagents provides this antibody for researchers studying gene regulation, stress adaptation, and cellular defense mechanisms.

UniProt: P53567

Pathways: Positive Regulation of Response to DNA Damage Stimulus