THRSP Antikörper (AA 1-146)

Produktnummer ABIN7868170

Der Kaninchen Polyklonal anti-THRSP Antikörper (ABIN7868170) detektiert spezifisch THRSP in ELISA, WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für THRSP Antikörper (AA 1-146) (ABIN7868170)

Target: THRSP (Thyroid Hormone Responsive (THRSP))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRSP Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-THRSP Antikörper

Bindungsspezifität: AA 1-146

Verwendungszweck: THRSP Antibody / Thyroid hormone-responsive protein

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human THRSP recombinant protein (Position: M1-W146) was used as the immunogen for the THRSP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the THRSP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the THRSP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu THRSP

Target: THRSP (Thyroid Hormone Responsive (THRSP))

Andere Bezeichnung: THRSP

Hintergrund: THRSP antibody detects Thyroid hormone-responsive protein, encoded by the THRSP gene on chromosome 11q13.5. THRSP antibody is widely applied in studies of lipid metabolism, endocrine regulation, and cancer biology. THRSP, also known as Spot14, is a nuclear protein induced by thyroid hormone and carbohydrate feeding. It is highly expressed in liver, adipose tissue, and lactating mammary gland, where it regulates lipogenesis by controlling transcription of lipogenic enzymes. In humans, THRSP expression correlates with metabolic state and hormonal regulation, making it a valuable marker for metabolic research.

Structurally, THRSP is a ~17 kDa acidic nuclear protein that lacks enzymatic activity but functions as a transcriptional regulator. It contains nuclear localization sequences and DNA-binding domains that interact with chromatin and transcription factors. Its regulation is tightly linked to nutritional and hormonal status, with strong induction by triiodothyronine (T3), glucose, and insulin.

Functionally, THRSP promotes lipogenesis by enhancing expression of genes such as fatty acid synthase and acetyl-CoA carboxylase. It plays an important role in lactation, where increased lipogenesis supports milk production. In liver, THRSP regulates triglyceride synthesis and influences lipid storage. Overexpression of THRSP drives lipid accumulation, while deficiency impairs lipid biosynthesis. Researchers use THRSP antibody to investigate lipid metabolism, endocrine signaling, and mammary gland physiology.

Clinically, THRSP is associated with metabolic diseases and cancer. Dysregulated THRSP expression contributes to obesity, fatty liver disease, and breast cancer. Elevated expression in breast tumors correlates with lipogenic phenotype and worse prognosis. As a hormone-responsive gene, THRSP also serves as a biomarker of thyroid hormone activity and metabolic adaptation. NSJ Bioreagents provides THRSP antibody for studies in metabolism, endocrinology, and oncology.

Experimentally, THRSP antibody is used in western blotting to detect the ~17 kDa protein, in immunohistochemistry to study expression in liver and mammary gland, and in immunofluorescence to analyze nuclear localization. Co-immunoprecipitation with THRSP antibody identifies chromatin-associated complexes involved in lipogenic gene regulation.

UniProt: Q92748