RPS19 Antikörper (AA 1-145)

Produktnummer ABIN7868158

Der Kaninchen Polyklonal anti-RPS19 Antikörper (ABIN7868158) detektiert spezifisch RPS19 in WB, ELISA, FACS, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für RPS19 Antikörper (AA 1-145) (ABIN7868158)

Target: RPS19 (Ribosomal Protein S19 (RPS19))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPS19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-RPS19 Antikörper

Bindungsspezifität: AA 1-145

Verwendungszweck: RPS19 Antibody / 40S ribosomal protein S19

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human RPS19 recombinant protein (Position: M1-H145) was used as the immunogen for the RPS19 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RPS19 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RPS19 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RPS19

Target: RPS19 (Ribosomal Protein S19 (RPS19))

Andere Bezeichnung: RPS19

Hintergrund: The RPS19 antibody targets 40S ribosomal protein S19, a structural component of the small ribosomal subunit encoded by the RPS19 gene. This protein is essential for ribosome biogenesis, rRNA maturation, and translation initiation. 40S ribosomal protein S19 interacts with ribosomal RNA and multiple assembly factors to promote 40S subunit stability and cytoplasmic export. The RPS19 antibody provides researchers with a high-specificity reagent to study ribosome assembly, protein synthesis, and ribosomopathies associated with defective ribosome production.

40S ribosomal protein S19 is synthesized in the cytoplasm and imported into the nucleolus, where ribosome assembly begins. It binds pre-rRNA intermediates and contributes to proper folding and cleavage of the 18S rRNA precursor. The RPS19 antibody enables detection of this essential component within ribosomal particles, supporting studies of translational regulation and nucleolar dynamics. Its nucleolar localization reflects its participation in early 40S subunit maturation steps.

Mutations in RPS19 are the most common cause of Diamond-Blackfan anemia (DBA), a congenital erythroid aplasia characterized by defective red blood cell production. Loss of 40S ribosomal protein S19 impairs ribosome biogenesis, activates p53-mediated stress responses, and reduces erythroid progenitor survival. The RPS19 antibody supports investigation of these pathogenic mechanisms by enabling quantification of protein levels in patient-derived cells and experimental models. It also helps identify how ribosomal stress contributes to bone marrow failure and developmental abnormalities.

In addition to its ribosomal role, 40S ribosomal protein S19 has extra-ribosomal functions in apoptosis regulation, inflammation, and cell signaling. It can be released extracellularly where it acts as a chemotactic factor for macrophages. The RPS19 antibody provides a valuable means of analyzing these non-canonical functions, revealing how ribosomal proteins can serve signaling roles beyond translation. Dysregulation of RPS19 has also been observed in several cancers, linking ribosome synthesis with oncogenic growth control.

The RPS19 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, yielding characteristic nucleolar and cytoplasmic staining. NSJ Bioreagents supplies this antibody with high specificity and reproducibility for molecular and cellular biology research. By enabling precise detection of 40S ribosomal protein S19, the RPS19 antibody supports studies of ribosome assembly, erythropoiesis, and human ribosomopathies.

UniProt: P39019

Pathways: Positive Regulation of Immune Effector Process, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly