ATOH7 Antikörper (AA 1-134)

Produktnummer ABIN7868103

Der Kaninchen Polyklonal anti-ATOH7 Antikörper wird verwendet zum Nachweis von ATOH7 in Proben von Zebrafisch (Danio rerio). Er wurde validiert für IHC (p).

Kurzübersicht für ATOH7 Antikörper (AA 1-134) (ABIN7868103)

Target: ATOH7 (Atonal Homolog 7 (ATOH7))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATOH7 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ATOH7 Antikörper

Bindungsspezifität: AA 1-134

Verwendungszweck: Zebrafish Atoh7 Antibody / Lakritz

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Atoh7 recombinant protein (amino acids M1-L134) was used as the immunogen for the Zebrafish Atoh7 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Atoh7 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Atoh7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ATOH7

Target: ATOH7 (Atonal Homolog 7 (ATOH7))

Andere Bezeichnung: Atoh7

Hintergrund: Atonal homolog 7 (Atoh7), also known as Lakritz, is a basic helix-loop-helix (bHLH) transcription factor that plays an essential role in retinal neurogenesis, particularly in the specification of retinal ganglion cells (RGCs). In zebrafish (Danio rerio), Atoh7 is critical for the early stages of eye development, where it governs the differentiation of progenitor cells into RGCs-the first retinal neurons to extend axons to the brain.

During zebrafish embryogenesis, atoh7 is expressed in retinal progenitor cells, and its activity initiates the genetic cascade required for RGC formation and optic nerve development. Mutations in atoh7, such as in the lakritz mutant, result in the complete absence of RGCs and a failure to form the optic nerve, making it a key model for studying retinal development, axonal pathfinding, and neuronal lineage commitment.

Given its conserved function across vertebrates, zebrafish Atoh7 is widely used in research on eye development, stem cell differentiation, and regenerative medicine targeting visual system repair. It also serves as a molecular marker for early neurogenesis in the retina.

UniProt: Q8AW52