CCL23 Antikörper (AA 1-120)

Produktnummer ABIN7868017

Der Maus Monoklonal anti-CCL23 Antikörper (Klon CCL23-4034) (ABIN7868017) detektiert spezifisch CCL23 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CCL23 Antikörper (AA 1-120) (ABIN7868017)

Target: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCL23 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CCL23-4034

Produktdetails anti-CCL23 Antikörper

Bindungsspezifität: AA 1-120

Verwendungszweck: CCL23 Antibody / MPIF-1

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-120) from the human protein was used as the immunogen for the CCL23 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CCL23 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Myeloid Progenitor Inhibitory Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CCL23

Target: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Andere Bezeichnung: CCL23

Hintergrund: Small inducible cytokine A23 precursor (CCL23), also called CK-b-8 and Myeloid Progenitor Inhibitory Factor 1 (MPIF-1), is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.

UniProt: P55773