GALP Antikörper (AA 1-116)

Produktnummer ABIN7867970

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GALP in ELISA und WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für GALP Antikörper (AA 1-116) (ABIN7867970)

Target: GALP (Galanin-Like Peptide (GALP))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GALP Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-GALP Antikörper

Bindungsspezifität: AA 1-116

Verwendungszweck: GALP Antibody / Galanin-like peptide

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human GALP recombinant protein (Position: M1-S116) was used as the immunogen for the GALP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GALP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GALP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GALP

Target: GALP (Galanin-Like Peptide (GALP))

Andere Bezeichnung: GALP

Hintergrund: GALP antibody detects Galanin-like peptide, a hypothalamic neuropeptide involved in energy balance, feeding behavior, and reproductive hormone regulation. The UniProt recommended name is Galanin-like peptide (GALP). This neuropeptide acts within the central nervous system to integrate metabolic, thermoregulatory, and neuroendocrine signals, linking energy status to reproductive function and stress adaptation.

Functionally, GALP antibody identifies a 60-amino-acid peptide derived from a larger precursor encoded by the GALP gene. The peptide binds to galanin receptors GALR1, GALR2, and GALR3, activating G protein-mediated signaling pathways that influence neuronal excitability and neuroendocrine secretion. GALP is expressed primarily in the arcuate nucleus and median eminence of the hypothalamus, where it regulates appetite, body temperature, and pituitary hormone release. Its expression is modulated by leptin, insulin, and circulating glucose levels, positioning GALP as a metabolic signal integrator.

The GALP gene is located on chromosome 19q13.43 and exhibits conserved expression in mammals, reflecting its importance in metabolic control. GALP neurons project to hypothalamic and extrahypothalamic regions involved in feeding and thermoregulation, including the paraventricular nucleus and dorsal raphe.

Pathologically, dysregulation of GALP signaling contributes to metabolic and neuroendocrine disorders such as obesity, infertility, and hypothalamic dysfunction. Reduced GALP expression is associated with leptin deficiency and disrupted reproductive cycling, while elevated levels influence energy expenditure and thermogenesis. Research using GALP antibody supports studies in neuroendocrinology, energy metabolism, and reproductive physiology.

GALP antibody is validated for immunohistochemistry, immunofluorescence, and ELISA to detect neuropeptides in hypothalamic and pituitary tissues. NSJ Bioreagents provides GALP antibody reagents optimized for studies in appetite regulation, metabolic homeostasis, and stress signaling.

Structurally, Galanin-like peptide shares sequence homology with galanin in its N-terminal region, allowing interaction with the same receptor family but with distinct potency and distribution. Post-translational processing of prepro-GALP yields the mature peptide with amidated C-terminus essential for receptor activation. This antibody enables analysis of GALP's role in central metabolic control and neuroendocrine integration.

UniProt: Q9UBC7