PVALB Antikörper (AA 1-110)

Produktnummer ABIN7867944

Der Maus Monoklonal anti-PVALB Antikörper wird verwendet zum Nachweis von PVALB in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für PVALB Antikörper (AA 1-110) (ABIN7867944)

Target: PVALB (Parvalbumin (PVALB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PVALB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PVALB-7601

Produktdetails anti-PVALB Antikörper

Bindungsspezifität: AA 1-110

Verwendungszweck: Parvalbumin Antibody / PVALB

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-110) from the human protein was used as the immunogen for the Parvalbumin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Parvalbumin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Parvalbumin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PVALB

Target: PVALB (Parvalbumin (PVALB))

Andere Bezeichnung: Parvalbumin

Hintergrund: The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100Alpha and beta, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin Alpha and parvalbumin beta, also designated oncomodulin (OCM). Structurally and evolutionarily conserved, parvalbumin Alpha and OCM proteins are distinct in expression and function. Parvalbumin Alpha, also designated parvalbumin (PV), is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues, including kidney and parathyroid. Research indicates that parvalbumin Alpha plays a significant role in muscle relaxation. OCM was originally thought to have expression restricted to neoplastic tissues, early embryonic cells and certain tumor cell lines. Recent research shows that OCM is also expressed and secreted by macrophages where, in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration. OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals. In humans, two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951). These genes encode proteins 109 amino acids in length which share 99 % sequence identity.

UniProt: P20472