Glutaredoxin 1 Antikörper (AA 1-106)

Produktnummer ABIN7867933

Der Kaninchen Polyklonal anti-Glutaredoxin 1 Antikörper (ABIN7867933) detektiert spezifisch Glutaredoxin 1 in WB, ELISA, IF, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Glutaredoxin 1 Antikörper (AA 1-106) (ABIN7867933)

Target: Glutaredoxin 1 (GRX1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutaredoxin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Glutaredoxin 1 Antikörper

Bindungsspezifität: AA 1-106

Verwendungszweck: GLRX Antibody / Glutaredoxin 1

Aufreinigung: Antigen affinity purified

Immunogen: A human recombinant partial protein (amino acids M1-Q106) was used as the immunogen for the GLRX antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GLRX antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GLRX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Glutaredoxin 1

Target: Glutaredoxin 1 (GRX1)

Andere Bezeichnung: GLRX

Hintergrund: GLRX (Glutaredoxin 1) is a small redox enzyme that belongs to the thioredoxin family and plays an essential role in maintaining cellular redox homeostasis. It catalyzes the reversible reduction of protein disulfides and mixed disulfides formed between proteins and glutathione, a process known as deglutathionylation. This activity regulates protein function, protects against oxidative stress, and ensures proper signal transduction. Researchers frequently use a GLRX antibody to investigate antioxidant defense systems, redox regulation, and stress responses.

GLRX is widely expressed in mammalian tissues, with particularly high levels in heart, liver, and skeletal muscle. Its enzymatic activity is critical in pathways that counteract oxidative damage and maintain the thiol status of proteins. Dysregulation of GLRX has been linked to cardiovascular disease, neurodegenerative disorders, and cancer, where imbalances in redox signaling contribute to disease pathology. Employing a GLRX antibody allows scientists to analyze protein expression, localization, and post-translational modifications in health and disease.

In addition to its protective role, GLRX has been implicated in apoptosis, inflammatory responses, and mitochondrial function. It also interacts with iron-sulfur cluster proteins, influencing mitochondrial biogenesis and energy metabolism. Because oxidative stress is a common hallmark of many diseases, GLRX remains an attractive target for translational research. Using a GLRX antibody provides a reliable approach for monitoring its activity and contribution to cellular redox control.

NSJ Bioreagents provides a high-quality GLRX antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a GLRX antibody from NSJ Bioreagents ensures consistent performance and reproducibility in studies of oxidative stress, redox regulation, and disease mechanisms.

UniProt: P35754

Pathways: Cell RedoxHomeostasis