FYCO1 Antikörper (AA 1-1019)

Produktnummer ABIN7867920

Der Kaninchen Polyklonal anti-FYCO1 Antikörper wird verwendet zum Nachweis von FYCO1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC und FACS.

Kurzübersicht für FYCO1 Antikörper (AA 1-1019) (ABIN7867920)

Target: FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FYCO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-FYCO1 Antikörper

Bindungsspezifität: AA 1-1019

Verwendungszweck: FYCO1 Antibody / FYVE and coiled-coil domain containing 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human FYCO1 recombinant protein (Position: M1-K1019) was used as the immunogen for the FYCO1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FYCO1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the FYCO1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu FYCO1

Target: FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))

Andere Bezeichnung: FYCO1

Hintergrund: FYCO1 antibody detects FYVE and coiled-coil domain containing 1, encoded by the FYCO1 gene. FYVE and coiled-coil domain containing 1 is a cytoplasmic protein that functions as an autophagy adaptor, linking autophagosomes to microtubule-based transport systems. FYCO1 antibody provides researchers with a key reagent for studying autophagy, vesicle trafficking, and disease mechanisms involving impaired cellular clearance.

FYVE and coiled-coil domain containing 1 contains a FYVE domain that binds phosphatidylinositol-3-phosphate on autophagosome membranes and a LC3-interacting region that recruits autophagy machinery. Research using FYCO1 antibody has shown that the protein couples autophagosomes to kinesin motors, promoting their transport along microtubules toward the cell periphery. This process facilitates autophagosome maturation and fusion with lysosomes.

Studies with FYCO1 antibody have revealed that loss-of-function mutations in FYCO1 cause autosomal recessive congenital cataracts. In lens epithelial cells, defective autophagy due to impaired FYCO1 activity leads to accumulation of damaged proteins and organelles, resulting in lens opacity. This genetic association highlights the clinical relevance of FYCO1 in ocular development and disease.

Dysregulation of FYVE and coiled-coil domain containing 1 has also been implicated in neurodegeneration and infection. Research using FYCO1 antibody has shown that altered expression affects autophagosome trafficking in neurons, contributing to accumulation of aggregates in neurodegenerative conditions. Pathogens such as Mycobacterium tuberculosis can manipulate FYCO1-mediated pathways, underscoring its significance in host-pathogen interactions.

FYCO1 antibody is widely applied in immunofluorescence, immunohistochemistry, and western blotting. Immunofluorescence highlights co-localization with LC3-positive autophagosomes, immunohistochemistry demonstrates tissue-specific expression, and western blotting quantifies levels in cells and tissues. These applications make FYCO1 antibody indispensable in autophagy and vesicle transport research.

By providing validated FYCO1 antibody reagents, NSJ Bioreagents supports studies into autophagy, cellular clearance, and disease. Detection of FYVE and coiled-coil domain containing 1 provides researchers with insight into how adaptor proteins regulate vesicle trafficking and pathology.

UniProt: Q9BQS8

Pathways: SARS-CoV-2 Protein Interaktom