Rekombinanter Gastrin Antikörper (AA 1-101)

Produktnummer ABIN7867908

Der Kaninchen Monoklonal anti-Gastrin Antikörper wird verwendet zum Nachweis von Gastrin in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter Gastrin Antikörper (AA 1-101) (ABIN7867908)

Target: Gastrin (GAST)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Gastrin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: GAST-8646R

Produktdetails anti-Gastrin Antikörper

Bindungsspezifität: AA 1-101

Verwendungszweck: Recombinant Gastrin Antibody

Aufreinigung: Protein A affinity

Immunogen: A portion of amino acids 1-101 from human GAST protein was used as the immunogen for the recombinant Gastrin antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Gastrin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant Gastrin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Gastrin

Target: Gastrin (GAST)

Andere Bezeichnung: Gastrin

Hintergrund: Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.

UniProt: P01350