IKK-alpha /IKK-beta Antikörper (pSer180, pSer181) (Biotin)

Produktnummer ABIN743305

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch IKK-alpha /IKK-beta in ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für IKK-alpha /IKK-beta Antikörper (pSer180, pSer181) (Biotin) (ABIN743305)

Target: IKK-alpha /IKK-beta

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKK-alpha /IKK-beta Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-IKK-alpha /IKK-beta Antikörper (Biotin)

Bindungsspezifität: pSer180, pSer181

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human IKK alpha/IKK beta around the phosphorylation site of Ser180/Ser181

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu IKK-alpha /IKK-beta

Target: IKK-alpha /IKK-beta

Andere Bezeichnung: IKK alpha / beta / 181

Hintergrund:

Synonyms: I Kappa B Kinase Alpha, IKKalpha, IKK alpha, IkappaB kinase, IkB kinase alpha subunit, IKBKA, IKK 1, IKK A, IKK a kinase, IKK1, IKKA, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, NFKBIKA, Nuclear Factor Kappa B Inhibitor Kinase Alpha, Nuclear factor NF kappa B inhibitor kinase alpha, Nuclear factor NFkappaB inhibitor kinase alpha, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor, TCF16, CHUK1, Conserved Helix Loop Helix Ubiquitous Kinase, Conserved helix loop ubiquitous kinase, I Kappa B Kinase 1, IKKA_HUMAN.

Background: Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.

Gen-ID: 1147