Plasma Cell Marker Antikörper

Produktnummer ABIN7865714

Dieser Maus Monoklonal Antikörper detektiert spezifisch Plasma Cell Marker in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Plasma Cell Marker Antikörper (ABIN7865714)

Target: Plasma Cell Marker

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: EBS-O-231

Produktdetails

Verwendungszweck: anti-Plasma-Cell-Marker mouse monoclonal, EBS-O-231, purified

Kreuzreaktivität (Details): not with rat

Aufreinigung: affinity chromatography

Immunogen: pancreatic cancer related serum mucin

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optional[ICC/IF_dilution]: 1:50-1:100 (1-2 μg/mL, microwave treatment in 10 mM citrate buffer pH 6.0 recommended)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: store at 2 - 8 °C

Antigendetails

Target: Plasma Cell Marker

Andere Bezeichnung: Plasma-Cell-Marker

Hintergrund: EBS-O-231 recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm, their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Positive control: Human toncil.