hCG Holo Antikörper

Produktnummer ABIN7865643

Der Maus Monoklonal anti-hCG Holo Antikörper wird verwendet zum Nachweis von hCG Holo in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für hCG Holo Antikörper (ABIN7865643)

Target: hCG Holo

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: HCGh25

Produktdetails

Verwendungszweck: anti-hCG Holo mouse monoclonal, HCGh25, purified

Aufreinigung: affinity chromatography

Immunogen: purified hCG

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

IHC-paraffin_dilution: 1:50-1:100 (1-2 μg/mL, microwave treatment in 10 mM citrate buffer pH 6.0 recommended)

IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: store at 2 - 8 °C

Antigendetails

Target: hCG Holo

Hintergrund: HCGh25 is very special because it reacts ONLY with intact-hCG and not with either free alpha- or free beta-chain of hCG. hCG is a glycoprotein composed of two non-identical, non-covalently linked polypeptide chains. The alpha subunit is identical among hCG, TSH, FSH and LH. While hCG is secreted in large quantities by normal trophoblasts, it is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. Besides trophoblastic tumors e.g. choriocarcinoma, large cell carcinoma, adenocarcinoma and squamous cell carcinoma of the lung are also positive in 90 % , 60 % and 20 % of cases respectively. hCG expression by non-trophoblastic tumors may indicate aggressive behavior. Positive control: JAR or TT Cells. Placenta.