Rekombinanter Keratin 10 Antikörper

Produktnummer ABIN7865509

Dieser Maus Monoklonal Antikörper detektiert spezifisch Keratin 10 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Keratin 10 Antikörper (ABIN7865509)

Target: Keratin 10 (KRT10)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: MSVA-610M

Produktdetails anti-Keratin 10 Antikörper

Expressionssystem: HEK-293 Cells

Verwendungszweck: Recombinant Cytokeratin 10 (Suprabasal Epithelial Marker) Antibody

Spezifität: This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Aufreinigung: Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant full-lenth human KRT10 protein.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Keratin 10

Target: Keratin 10 (KRT10)

Andere Bezeichnung: Cytokeratin 10

Hintergrund:

BCIE, BIE, EHK, Keratin Type I Cytoskeletal 10, KRT10

Skin: All squamous epithelial cells (except the basal cell layer) should show strong cytoplasmic staining, while the basal cell layer remains KRT10 negative or shows only minimal staining.

Molekulargewicht: 56.5kDa

Gen-ID: 3858, 99936

UniProt: P13645