Cytokeratin 13 Antikörper

Produktnummer ABIN7865510

Der Maus Monoklonal anti-Cytokeratin 13 Antikörper wird verwendet zum Nachweis von Cytokeratin 13 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Cytokeratin 13 Antikörper (ABIN7865510)

Target: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cytokeratin 13 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: MSVA-613M

Produktdetails anti-Cytokeratin 13 Antikörper

Verwendungszweck: Cytokeratin 13 (Non-Keratinized Squamous Epithelial Marker) Antibody

Spezifität: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs)that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with Cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.

Aufreinigung: Ab produced in CHO cell mammalian-based expression system.

Immunogen: esophageal keratins of rabbit origin

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Cytokeratin 13

Target: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Andere Bezeichnung: Cytokeratin 13

Hintergrund:

CK13, Cytokeratin-13, Keratin Type I Cytoskeletal 13, Keratin-13, KRT13, Type I Cytoskeletal 13, WSN2

Tonsil: All squamous epithelial cells of the surface squamous epithelium (except the basal layer) and a fraction of squamous cells of the crypts should show strong KRT13 staining.

Molekulargewicht: 52kDa

Gen-ID: 3860, 654550

UniProt: P13646