LY75/DEC-205 Antikörper (AA 1006-1130)

Produktnummer ABIN7863090

Der Maus Monoklonal anti-LY75/DEC-205 Antikörper (Klon CD205-3720) (ABIN7863090) detektiert spezifisch LY75/DEC-205 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LY75/DEC-205 Antikörper (AA 1006-1130) (ABIN7863090)

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LY75/DEC-205 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: CD205-3720

Produktdetails anti-LY75/DEC-205 Antikörper

Bindungsspezifität: AA 1006-1130

Verwendungszweck: CD205 / LY75 / DEC-205 Antibody

Spezifität: DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Aufreinigung: 200ug/ml of recombinant MAb purified by Protein A/G.

Immunogen: Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu LY75/DEC-205

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Andere Bezeichnung: CD205

Hintergrund:

C-type lectin domain family 13 member B, CD205 antigen, CLEC13B, DEC205, gp200 MR6, LY75, Lymphocyte antigen 75, Renal Cell Carcinoma (gp200)

Human tonsil, Thymus or Lymph Node.

Molekulargewicht: 198kDa

Gen-ID: 4065, 100526664, 153563

UniProt: O60449