Rekombinanter Smoothelin Antikörper

Produktnummer ABIN7862098

Der Kaninchen Monoklonal anti-Smoothelin Antikörper (Klon SMTN-2320R) (ABIN7862098) detektiert spezifisch Smoothelin in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Smoothelin Antikörper (ABIN7862098)

Target: Smoothelin (SMTN)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Smoothelin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: SMTN-2320R

Produktdetails anti-Smoothelin Antikörper

Verwendungszweck: Recombinant Smoothelin (Differentiated Smooth Muscle Marker) Antibody

Spezifität: Smoothelin is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. It is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this antibody an attractive diagnostic tool. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics (-).

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human Smoothelin (SMTN) protein

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Smoothelin

Target: Smoothelin (SMTN)

Andere Bezeichnung: Smoothelin

Hintergrund:

FLJ35168, FLJ35365, FLJ35620, FLJ38597, Smoothelin, SMSMO, Smtn, SMTN_HUMAN

Human smooth muscle.

Molekulargewicht: 59/110kDa (short/long isoforms|respectively)

Gen-ID: 6525, 149098

UniProt: P53814