SNAPC4 Antikörper

Produktnummer ABIN7862096

Dieser Maus Monoklonal Antikörper detektiert spezifisch SNAPC4 in IHC und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SNAPC4 Antikörper (ABIN7862096)

Target: SNAPC4 (Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa (SNAPC4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SNAPC4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: PCRP-SNAPC4-3A7

Produktdetails anti-SNAPC4 Antikörper

Verwendungszweck: SNAPC4 Antibody

Spezifität: TATA-box binding protein (TBP) interactions with TBP-associated factors (TAFs) are required for the transcription of RNA polymerases. One particular TBP-TAF complex, snRNA-activating protein complex (SNAPC), is unusual in that it regulates basal transcription of both RNA polymerase II and III by binding specifically to a non-TATA-box proximal sequence element (PSE). SNAPC consists of five subunits of varying size. SNAPC binds to Oct-1 and TBP, which are activators of snRNA and RNA polymerases, respectively. The POU domain of Oct-1 binds to SNAPC 190 and effectively recruits SNAPC to the PSE. The cooperative binding of SNAPC and Oct-1 to their respective sequence elements is mediated by a nucleosome positioned between the two sequence elements. SNAPC 19 mediates the assembly of the subunits to form a functional SNAPC transcription regulator. SNAPC 50 (also designated PTF≤) contains two zinc finger motifs and binds to SNAPC 43 (also designated PTFé 79oΩ) but not SNAPC 45 (PTFé 79oΩ).

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human SNAPC4 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu SNAPC4

Target: SNAPC4 (Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa (SNAPC4))

Andere Bezeichnung: SNAPC4

Hintergrund:

FLJ13451, PTFalpha, SNAP190

Human tonsil. HeLa or HDLM-2 cells.

Molekulargewicht: 200kDa

Gen-ID: 6621, 446091

UniProt: Q5SXM2