Rekombinanter ROR gamma Antikörper

Produktnummer ABIN7862020

Der Kaninchen Monoklonal anti-ROR gamma Antikörper (Klon RORC-8017R) (ABIN7862020) detektiert spezifisch ROR gamma in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter ROR gamma Antikörper (ABIN7862020)

Target: ROR gamma

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: RORC-8017R

Produktdetails

Verwendungszweck: Recombinant ROR-gamma / RORC (RAR-related Orphan Receptor C) Antibody

Spezifität: Retina-associated orphan receptors (RORs) contains three subtypes: RORé 79oΩ, RORé 79oΩ, and RORé 79oΩ. They are widely distributed in body tissues, and most of them can directly enter the nucleus to regulate the transcription of target genes, thus showing different tissue specificity and participating in different physiological processes. In particular, RORé 79oΩ and RORé 79oΩ play an important role in mediating Th17 cell differentiation. RORé 79oΩ can be divided into RORé 79oΩ1 and RORé 79oΩ2 (RORé 79oΩ T), which show different tissue specificity. ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ double positive thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTi) cells of lymphoid organs. At present, RORé 79oΩ T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORé 79oΩ T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human ROR gamma T protein

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Antigendetails

Target: ROR gamma

Andere Bezeichnung: ROR-gamma

Hintergrund:

Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR

MOLT4 cells. Human lymphocytes. Human liver or skeletal muscle tissue.

Molekulargewicht: 55kDa

Gen-ID: 6097

UniProt: P51449-2