PRDM1 Antikörper

Produktnummer ABIN7864854

Der Maus Monoklonal anti-PRDM1 Antikörper wird verwendet zum Nachweis von PRDM1 in Proben von Human und Maus. Er wurde validiert für FACS und IF.

Kurzübersicht für PRDM1 Antikörper (ABIN7864854)

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRDM1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: PCRP-PRDM1-2B9

Produktdetails anti-PRDM1 Antikörper

Verwendungszweck: PRDM1 / BLIMP-1 Antibody

Spezifität: The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human PRDM1 protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu PRDM1

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Andere Bezeichnung: PRDM1

Hintergrund:

B Lymphocyte Induced Maturation Protein 1 , Beta-interferon gene positive regulatory domain I-binding factor , BLIMP1 , Positive Regulatory Domain I Binding Factor 1 , PR domain containing 1 with ZNF domain isoform 2 , PR domain zinc finger protein 1 , PR domain-containing protein 1 , PRDI-BF1 , PRDI-binding factor 1

HeLa or MCF-7 cells.

Molekulargewicht: 114.8kDa

Gen-ID: 639, 436023

Pathways: Regulation of Muscle Cell Differentiation