NMI Antikörper

Produktnummer ABIN7863575

Dieser Maus Monoklonal Antikörper detektiert spezifisch NMI in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NMI Antikörper (ABIN7863575)

Target: NMI (N-Myc (And STAT) Interactor (NMI))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NMI Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PCRP-NMI-1C1

Produktdetails anti-NMI Antikörper

Verwendungszweck: N myc (and STAT) Interactor / NMI Antibody

Spezifität: Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human NMI protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu NMI

Target: NMI (N-Myc (And STAT) Interactor (NMI))

Andere Bezeichnung: N myc Interactor

Hintergrund:

N myc (and STAT) interactor, N myc interactor, NMI, NMYC and STAT interactor, NMYC interactor

HeLa or K562 cells.

Molekulargewicht: 38kDa

Gen-ID: 9111, 54483

UniProt: Q13287