MPZ Antikörper

Produktnummer ABIN7864350

Der Maus Monoklonal anti-MPZ Antikörper (Klon MPZ-7390) (ABIN7864350) detektiert spezifisch MPZ in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MPZ Antikörper (ABIN7864350)

Target: MPZ (Myelin Protein Zero (MPZ))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MPZ Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: MPZ-7390

Produktdetails anti-MPZ Antikörper

Verwendungszweck: Myelin Protein Zero / MPZ Antibody

Spezifität: Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50 % of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human MPZ protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Andere Bezeichnung: Myelin Protein Zero

Hintergrund:

Charcot Marie Tooth neuropathy 1B, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, Myelin protein P0, Myelin protein zero, MYP0_HUMAN, P0

Peripheral nerve cells.

Molekulargewicht: 28kDa

Gen-ID: 4359, 591486

UniProt: P25189