Rekombinanter L1CAM Antikörper

Produktnummer ABIN7861626

Der Maus Monoklonal anti-L1CAM Antikörper wird verwendet zum Nachweis von L1CAM in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter L1CAM Antikörper (ABIN7861626)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser L1CAM Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: RL1CAM-9163

Produktdetails anti-L1CAM Antikörper

Verwendungszweck: Recombinant CD171 / NCAM-L1 (L1 Cell Adhesion Molecule) Antibody

Spezifität: L1 (L1 cell adhesion molecule) also known as CAML1, CD171, and HSAS is an adhesion molecule which plays an important role in the nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). This mouse monoclonal antibody recognizes the sequence immediately NH2-terminal to the tyrosine-based motif and binds L1 only when Y1176 is dephosphorylated. Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human L1CAM protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Andere Bezeichnung: CD171

Hintergrund:

CAML1, HSAS1, Hyd, L1 Cell Adhesion Molecule, L1-NCAM, MASA, MIC5, NCAM-L1, Nerve-growth factor-inducible large external glycoprotein, Neural cell adhesion molecule L1, NILE, S10, SPG1

Human brain.

Molekulargewicht: full-length isoforms: 140/180/220kDa, proteolytically cleaved form:85 kDa

Gen-ID: 3897, 52818

UniProt: P32004

Pathways: Synaptic Membrane