ATRX Antikörper

Produktnummer ABIN7863972

Dieser Maus Monoklonal Antikörper detektiert spezifisch ATRX in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ATRX Antikörper (ABIN7863972)

Target: ATRX (helicase 2, X-linked (ATRX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: ATRX-7940

Produktdetails anti-ATRX Antikörper

Verwendungszweck: ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody

Spezifität: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 é 79oΩ to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with é 79oΩ thalassemia or ATRX syndrome

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human ATRX protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX

Hintergrund:

Alpha thalassemia/mental retardation syndrome X linked homolog, ATP-dependent helicase ATRX, ATR2, ATRX, DNA-dependent ATPase and helicase, MRXHF1, RAD54, RAD54L, SFM1, SHS, Transcriptional regulator ATRX, X-linked helicase II, X-linked nuclear protein, XH2, XNP, Znf-HX

adrenal|Human pancreas|kidney|ovary|prostate or stomach.

Molekulargewicht: 280kDa

Gen-ID: 546, 533526, 653797

UniProt: P46100