CCAR2 Antikörper

Produktnummer ABIN7864161

Der Maus Monoklonal anti-CCAR2 Antikörper wird verwendet zum Nachweis von CCAR2 in Proben von Human. Er wurde validiert für IHC und FACS.

Kurzübersicht für CCAR2 Antikörper (ABIN7864161)

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCAR2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: PCRP-KIAA1967-1D10

Produktdetails anti-CCAR2 Antikörper

Verwendungszweck: KIAA1967 / DBC1 / CCAR2 Antibody

Spezifität: DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF±, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF±-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER±, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human CCAR2 / KIAA1967 protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu CCAR2

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Andere Bezeichnung: KIAA1967

Hintergrund:

CCAR2, Cell division cycle and apoptosis regulator protein 2, DBC.1, DBC1, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, K1967_HUMAN, KIAA1967, NET35, p30 DBC, p30DBC

Expressed ubiquitously in normal tissues. Expressed in 84 to 100 % of neoplastic breast, lung, and colon tissues.

Molekulargewicht: 102.9kDa

Gen-ID: 57805, 433722

UniProt: Q8N163