MX1 Antikörper (AA 400-592)

Produktnummer ABIN7864356

Dieser Maus Monoklonal Antikörper detektiert spezifisch MX1 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MX1 Antikörper (AA 400-592) (ABIN7864356)

Target: MX1 (Myxovirus Resistance Protein 1 (MX1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MX1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: MX1-7529

Produktdetails anti-MX1 Antikörper

Bindungsspezifität: AA 400-592

Verwendungszweck: MX1 / MX dynamin like GTPase 1 Antibody

Spezifität: The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa400-592) of human MX1 protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu MX1

Target: MX1 (Myxovirus Resistance Protein 1 (MX1))

Andere Bezeichnung: MX1

Hintergrund:

Human interferon regulated resistance GTP binding protein MXA, IFI78K, Interferon induced GTP binding protein Mx1, Interferon inducible protein p78, Interferon regulated resistance GTP binding protein MxA, MxA, Myxoma resistance protein 1, Myxovirus (influenza virus) resistance 1 interferon inducible, N-terminally processed

breast cancer or colon cancer tissues.|Human spleen|Tonsil

Molekulargewicht: 72kDa

Gen-ID: 4599, 517307

UniProt: P20591