GBP1 Antikörper (AA 400-592)

Produktnummer ABIN7864723

Der Maus Monoklonal anti-GBP1 Antikörper (Klon GBP1-7618) (ABIN7864723) detektiert spezifisch GBP1 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GBP1 Antikörper (AA 400-592) (ABIN7864723)

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GBP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: GBP1-7618

Produktdetails anti-GBP1 Antikörper

Bindungsspezifität: AA 400-592

Verwendungszweck: GBP1 Antibody

Spezifität: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa400-592) of human GBP1 protein (exact sequence is proprietary)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Andere Bezeichnung: GBP1

Hintergrund:

GTP binding protein 1, Guanine nucleotide binding protein 1, Guanylate binding protein 1 interferon inducible 67 kDa, HuGBP1, Interferon induced guanylate binding protein 1, OTTHUMP00000012352

Human colon or cerebral cortex tissue.

Molekulargewicht: 67kDa

Gen-ID: 2633, 62661

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin