Factor VII Antikörper (AA 366-466)

Produktnummer ABIN7862776

Der Maus Monoklonal anti-Factor VII Antikörper (Klon F7-3618) (ABIN7862776) detektiert spezifisch Factor VII in IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Factor VII Antikörper (AA 366-466) (ABIN7862776)

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Factor VII Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Klon: F7-3618

Produktdetails anti-Factor VII Antikörper

Bindungsspezifität: AA 366-466

Verwendungszweck: Coagulation Factor VII / F7 Antibody

Spezifität: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 366-466) of human F7 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Factor VII

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Andere Bezeichnung: Coagulation Factor VII

Hintergrund:

Eptacog alfa, Factor VII heavy chain, Factor VII light chain, FVII coagulation protein, Proconvertin, Serum prothrombin conversion accelerator (SPCA)

Human liver or gastric carcinoma.

Molekulargewicht: 200/80/73/50/43 kDa

Gen-ID: 2155, 36989

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling