Vitamin D-Binding Protein Antikörper (AA 35-175)

Produktnummer ABIN7862888

Dieser Maus Monoklonal Antikörper detektiert spezifisch Vitamin D-Binding Protein in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Vitamin D-Binding Protein Antikörper (AA 35-175) (ABIN7862888)

Target: Vitamin D-Binding Protein (GC)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Vitamin D-Binding Protein Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: VDBP-4482

Produktdetails anti-Vitamin D-Binding Protein Antikörper

Bindungsspezifität: AA 35-175

Verwendungszweck: GC Vitamin D Binding Protein Antibody

Spezifität: Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 35-175) of human GC protein (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Vitamin D-Binding Protein

Target: Vitamin D-Binding Protein (GC)

Andere Bezeichnung: GC Vitamin D Binding Protein

Hintergrund:

DBP/GC, Gc globulin, GRD3, Group specific component vitamin D binding protein, hDBP, VDB, VDBG, VDBP, Vitamin D binding alpha globulin, Vitamin D-binding protein

Human liver, kidney or pancreas.

Molekulargewicht: 53kDa.

Gen-ID: 2638, 418497

UniProt: P02774

Pathways: Metabolism of Steroid Hormones and Vitamin D, Monocarboxylic Acid Catabolic Process