Rekombinanter SOX11 Antikörper (AA 300-400)

Produktnummer ABIN7863416

Der Kaninchen Monoklonal anti-SOX11 Antikörper (Klon SOX11-3235R) (ABIN7863416) detektiert spezifisch SOX11 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter SOX11 Antikörper (AA 300-400) (ABIN7863416)

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SOX11 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: SOX11-3235R

Produktdetails anti-SOX11 Antikörper

Bindungsspezifität: AA 300-400

Verwendungszweck: Recombinant SOX11 (Mantle Cell Lymphoma Marker) Antibody

Spezifität: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa300-400) of human SOX11 protein

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu SOX11

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Andere Bezeichnung: SOX11

Hintergrund:

SOX11, SRY (sex determining region Y) box 11, SRY related HMG box gene 11, Transcription factor SOX-11

A431 or Y79 cells. Human cervix or mantle cell lymphoma (MCL).

Molekulargewicht: 47kDa

Gen-ID: 6664, 432638

UniProt: P35716

Pathways: Tube Formation