RBP4 Antikörper (AA 29-148)

Produktnummer ABIN7863339

Der Maus Monoklonal anti-RBP4 Antikörper wird verwendet zum Nachweis von RBP4 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für RBP4 Antikörper (AA 29-148) (ABIN7863339)

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RBP4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: RBP4-4049

Produktdetails anti-RBP4 Antikörper

Bindungsspezifität: AA 29-148

Verwendungszweck: RBP4 / Retinol Binding Protein 4 Antibody

Spezifität: Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa29-148) of human RBP4 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu RBP4

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Andere Bezeichnung: RBP4

Hintergrund:

Plasma retinol binding protein 4 (PRBP), RDCCAS, Retinol binding protein 4 interstitial

HeP-G2 cells. Human kidney, pancreas or liver tissues.

Molekulargewicht: 25kDa

Gen-ID: 5950, 50223

UniProt: P02753

Pathways: Regulatorische RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response