DBH Antikörper (AA 200-400)

Produktnummer ABIN7864919

Der Maus Monoklonal anti-DBH Antikörper (Klon DBH-7222) (ABIN7864919) detektiert spezifisch DBH in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für DBH Antikörper (AA 200-400) (ABIN7864919)

Target: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DBH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: DBH-7222

Produktdetails anti-DBH Antikörper

Bindungsspezifität: AA 200-400

Verwendungszweck: DBH / Dopamine Beta-Hydroxylase Antibody

Spezifität: Dopamine ≤-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-400) of human DBH protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu DBH

Target: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Andere Bezeichnung: DBH

Hintergrund:

dbh, DBM, Dopamine beta hydroxylase, Dopamine beta monooxygenase, Dopamine beta-hydroxylase (dopamine beta-monooxygenase), Soluble dopamine beta-hydroxylase

Human adrenal gland or adrenal pheochromocytoma.

Molekulargewicht: 78/84 kDa

Gen-ID: 1621, 591890

UniProt: P09172

Pathways: Carbohydrate Homeostasis