TGF-beta Antikörper (AA 200-390)

Produktnummer ABIN7864527

Der Maus Monoklonal anti-TGF-beta Antikörper wird verwendet zum Nachweis von TGF-beta in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für TGF-beta Antikörper (AA 200-390) (ABIN7864527)

Target: TGF-beta (TGFb)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGF-beta Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TGFB-7240

Produktdetails anti-TGF-beta Antikörper

Bindungsspezifität: AA 200-390

Verwendungszweck: TGF-beta (Transforming Growth Factor beta) Antibody

Spezifität: This MAb recognizes TGF beta 1, 2 and 3. Three TGF≤s have been identified in mammals. TGF≤1, TGF≤2 and TGF≤3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF≤ requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF≤3 protein has approximately 80 % identity to the mature region of both TGF≤1 and TGF≤2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF≤ s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells. 79oΩ

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-390) of human TGFB protein

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu TGF-beta

Target: TGF-beta (TGFb)

Andere Bezeichnung: TGF-beta

Hintergrund:

ARVD, BSC 1 cell growth inhibitor, CED, Cetermin, Diaphyseal dysplasia 1 (DPD1), Glioblastoma derived T cell suppressor factor (G TSF), Latency-associated peptide (LAP), Polyergin, Transforming growth factor beta 1 (TGF beta1 or TGFB1), TGF beta2 (TGFB2), TGF beta3 (TGFB3), TGFbeta (TGFB)

Salivary gland carcinoma

Molekulargewicht: 13kDa

Gen-ID: 7040, 645227

UniProt: P01137

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus