AMBP Antikörper (AA 200-353)

Produktnummer ABIN7859443

Der Maus Monoklonal anti-AMBP Antikörper (Klon AMBP-4536) (ABIN7859443) detektiert spezifisch AMBP in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für AMBP Antikörper (AA 200-353) (ABIN7859443)

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AMBP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: AMBP-4536

Produktdetails anti-AMBP Antikörper

Bindungsspezifität: AA 200-353

Verwendungszweck: AMBP (Alpha 1 Microglobulin) / Bikunin Antibody

Spezifität: The AMBP (±-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated ±-1-Microglobulin and Bikunin. ±-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, ±-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-±-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike ±-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-353) of human AMBP protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu AMBP

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Andere Bezeichnung: AMBP

Hintergrund:

A1M, Alpha 1 microglobulin/bikunin precursor, Alpha 1 microglycoprotein, Bikunin, Complex-forming glycoprotein heterogeneous in charge, EDC1, Growth inhibiting protein 19, HCP, HI30, IATIL, ITI, ITI-LC, ITIL, Microglobulin (alpha 1), Protein AMBP, Protein HC, Trypstatin, Uristatin, Uronic-acid-rich protein, UTI

Human liver or placenta.

Molekulargewicht: 30kDa

Gen-ID: 259, 436911