GBX2 Antikörper (AA 150-350)

Produktnummer ABIN7859213

Dieser Maus Monoklonal Antikörper detektiert spezifisch GBX2 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GBX2 Antikörper (AA 150-350) (ABIN7859213)

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GBX2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: GBX2-7235

Produktdetails anti-GBX2 Antikörper

Bindungsspezifität: AA 150-350

Verwendungszweck: GBX2 / Gastrulation Brain Homeobox 2 Antibody

Spezifität: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis, GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa150-350) of human GBX2 protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu GBX2

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Andere Bezeichnung: GBX2

Hintergrund:

Gastrulation and brain-specific homeobox protein 2, Gastrulation brain homeobox 2, Homeobox protein GBX2, Homeobox protein STRA7, Mmoxa

Human placenta or brain.

Molekulargewicht: 37kDa

Gen-ID: 2637, 184945

Pathways: Dopaminergic Neurogenesis