APOH Antikörper (AA 145-345)

Produktnummer ABIN7863954

Der Maus Monoklonal anti-APOH Antikörper (Klon APOH-3682) (ABIN7863954) detektiert spezifisch APOH in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für APOH Antikörper (AA 145-345) (ABIN7863954)

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APOH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: APOH-3682

Produktdetails anti-APOH Antikörper

Bindungsspezifität: AA 145-345

Verwendungszweck: Apolipoprotein H / APOH Antibody

Spezifität: Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa145-345) of human APOH protein (exact sequence is proprietary)

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu APOH

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Andere Bezeichnung: Apolipoprotein H

Hintergrund:

Activated protein C-binding protein, Anticardiolipin cofactor, APC inhibitor, Apo-H, apolipoprotein H (beta-2-glycoprotein I), B2G1, B2GP1, B2GPI, Beta 2 glycoprotein I precursor, Beta(2)GPI, BG, Glycoprotein 1, beta-2,

Human liver.

Molekulargewicht: 38kDa

Gen-ID: 350, 445358

UniProt: P02749