BCOR Antikörper (AA 100-400)

Produktnummer ABIN7864482

Der Maus Monoklonal anti-BCOR Antikörper (Klon BCOR-1311) (ABIN7864482) detektiert spezifisch BCOR in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BCOR Antikörper (AA 100-400) (ABIN7864482)

Target: BCOR (BCL6 Co-Repressor (BCOR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCOR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: BCOR-1311

Produktdetails anti-BCOR Antikörper

Bindungsspezifität: AA 100-400

Verwendungszweck: BCOR Antibody

Spezifität: Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFé 79oΩB expression, thereby inhibiting NFé 79oΩB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 100-400) of human BCOR protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu BCOR

Target: BCOR (BCL6 Co-Repressor (BCOR))

Andere Bezeichnung: BCOR

Hintergrund:

ANOP2, BCL 6 interacting corepressor, BCL6 interacting corepressor, BCoR, KIAA1575, MAA2, MCOPS2

Ubiquitously expression.

Molekulargewicht: 192kDa

Gen-ID: 54880, 659681

UniProt: Q6W2J9