Haptoglobin Antikörper (AA 100-250)

Produktnummer ABIN7862942

Der Maus Monoklonal anti-Haptoglobin Antikörper wird verwendet zum Nachweis von Haptoglobin in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für Haptoglobin Antikörper (AA 100-250) (ABIN7862942)

Target: Haptoglobin (HP)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Haptoglobin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: HP-3837

Produktdetails anti-Haptoglobin Antikörper

Bindungsspezifität: AA 100-250

Verwendungszweck: Haptoglobin (HP) Antibody

Spezifität: Haptoglobin (Hp) is a blood plasma protein that functions to bind free Hemoglobin that has been released from erythrocytes, thereby inhibiting its oxidative activity. During this process, Haptoglobin sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. This function suggests that Haptoglobin concentrations may increase in response to inflammation. The resulting Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial system. Due to cleavage of a common precursor protein during protein synthesis, Haptoglobin consists of two a and two b chains, connected by disulfide bridges. In human, Haptoglobin exists in two allelic forms designated Haptoglobin 1 (Hp1) and Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene duplication. There are three known phenotypes of human Haptoglobin: Hp1-1, Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular disease pathology and a susceptibility to Parkinson s and Crohn s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia, the abnormal breakdown of red blood cells. Haptoglobin is expressed in mammalian hepatocytes as well as other tissues such as skin, lung and kidney.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa100-250) of human HP protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Haptoglobin

Target: Haptoglobin (HP)

Andere Bezeichnung: Haptoglobin

Hintergrund:

Binding peptide (BP), Haptoglobin alpha chain / alpha(1S) beta, Haptoglobin alpha(2FS) beta, Haptoglobin beta chain, Haptoglobin, alpha polypeptide, Haptoglobin, beta polypeptide, HP, HP2 ALPHA2, HPA1S, HPT, MGC111141, Zonulin

Human liver.

Molekulargewicht: 15-18 kDa ( chain), 45kDa ( chain)

Gen-ID: 3240, 513711, 702099

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis