T-Bet Antikörper (AA 1-200)

Produktnummer ABIN7858720

Der Maus Monoklonal anti-T-Bet Antikörper (Klon TBX21-6724) (ABIN7858720) detektiert spezifisch T-Bet in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für T-Bet Antikörper (AA 1-200) (ABIN7858720)

Target: T-Bet

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser T-Bet Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TBX21-6724

Produktdetails anti-T-Bet Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: T-bet / Tbox-bet / TBX21 Antibody

Spezifität: T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine, IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1-200) of human TBX21 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu T-Bet

Target: T-Bet

Hintergrund:

T box expressed in T cells, T box protein 21, T box transcription factor TBX21, T cell specific T box transcription factor T bet, T PET, T-cell-specific T-box transcription factor T-bet, TBET, TBLYM, TPET, Transcription factor TBLYM

Human tonsil|non-Hodgkin s lymphoma or spleen. T-cell specific.

Molekulargewicht: 62kDa

Gen-ID: 30009, 272409

UniProt: Q9UL17