Neurogenin 3 Antikörper (AA 1-200)

Produktnummer ABIN7864474

Der Maus Monoklonal anti-Neurogenin 3 Antikörper (Klon NGN3-1809) (ABIN7864474) detektiert spezifisch Neurogenin 3 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Neurogenin 3 Antikörper (AA 1-200) (ABIN7864474)

Target: Neurogenin 3 (NEUROG3)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Neurogenin 3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: NGN3-1809

Produktdetails anti-Neurogenin 3 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody

Spezifität: This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human NEUROG3 protein (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu Neurogenin 3

Target: Neurogenin 3 (NEUROG3)

Andere Bezeichnung: NEUROG3

Hintergrund:

ATH4B, Atoh5, bHLHa7, Class A basic helix-loop-helix protein 7, Math4B, NEUROG3, Neurogenin-3, Neurogenin3, NGN-3, ngn3, Protein atonal homolog 5

colon|HeLa cells. Human fetal gut|liver or heart.

Molekulargewicht: 23.54kDa

Gen-ID: 50674, 288655

UniProt: Q9Y4Z2