CD3G Antikörper (AA 1-182)

Produktnummer ABIN7865059

Der Maus Monoklonal anti-CD3G Antikörper (Klon CD3G-8794) (ABIN7865059) detektiert spezifisch CD3G in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CD3G Antikörper (AA 1-182) (ABIN7865059)

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD3G Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: CD3G-8794

Produktdetails anti-CD3G Antikörper

Bindungsspezifität: AA 1-182

Verwendungszweck: CD3G / CD3beta1 / TCR beta Antibody

Spezifität: The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosinebased activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-182) of human CD3G protein (exact sequence is proprietary)

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu CD3G

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Andere Bezeichnung: CD3G

Hintergrund:

CD3g antigen gamma polypeptide (TiT3 complex), CD3g molecule gamma (CD3 TCR complex), T cell antigen receptor complex gamma subunit of T3, T-cell surface glycoprotein CD3 gamma chain, T3G

Human colon|tonsil or spleen.

Molekulargewicht: 18-28kDa

Gen-ID: 917, 2259

UniProt: P09693

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events