Rekombinanter Gastrin Antikörper (AA 1-101)

Produktnummer ABIN7865405

Der Kaninchen Monoklonal anti-Gastrin Antikörper wird verwendet zum Nachweis von Gastrin in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter Gastrin Antikörper (AA 1-101) (ABIN7865405)

Target: Gastrin (GAST)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Gastrin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: GAST-8646R

Produktdetails anti-Gastrin Antikörper

Bindungsspezifität: AA 1-101

Verwendungszweck: Recombinant Gastrin Antibody

Spezifität: Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-101) of human GAST protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Gastrin

Target: Gastrin (GAST)

Andere Bezeichnung: Gastrin

Hintergrund:

Component II, GAS, Gast, Gastrin component I, Gastrin component II, Gastrin component III, Gastrin precursor, Gastrin-14, Gastrin-17, Gastrin-34, Gastrin-52, Gastrin-6, Gastrin-71

Human pituitary, stomach or gastric carcinoma.

Molekulargewicht: 2/4/14kDa

Gen-ID: 2520, 2681

UniProt: P01350