RENT1/UPF1 Antikörper

Produktnummer ABIN7858047

Der Maus Monoklonal anti-RENT1/UPF1 Antikörper wird verwendet zum Nachweis von RENT1/UPF1 in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für RENT1/UPF1 Antikörper (ABIN7858047)

Target: RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RENT1/UPF1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: NY1-1-1B6

Produktdetails anti-RENT1/UPF1 Antikörper

Verwendungszweck: RENT1 / hUPF1 Antibody

Spezifität: In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability. Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase. Rent1 protein has nucleic-acid-dependent ATPase activity and 5' to 3' helicase activity. In addition, Rent1 is an RNA-binding protein whose activity is modulated by ATP and directly interacts with Rent2, which is a mammalian homolog of Upf2p. Two mammalian orthologs to Upf3p, Rent3a and Rent3b, are encoded by two separate genes. Rent3b (also known as Rent3X) is encoded by a X-linked gene and localizes primarily to the nucleus, while Rent1 and Rent2 localize primarily in the cytoplasm. Specific Rent3 protein interactions with Y14 and spliced mRNA suggest Rent3a and Rent3b serve as a link between splicing and NMD in the cytoplasm.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A.

Immunogen: Recombinant human UPF1 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu RENT1/UPF1

Target: RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))

Andere Bezeichnung: RENT1

Hintergrund:

KIAA0221, RENT1, UPF1, UTF, smg-2, pNORF1

HeLa cells.

Molekulargewicht: 124kDa

Gen-ID: 5976

UniProt: Q92900

Pathways: SARS-CoV-2 Protein Interaktom