Rekombinanter p40 (p63 Delta) (AA 1-200) Antikörper

Produktnummer ABIN7864324

Der Kaninchen Monoklonal anti-p40 (p63 Delta) Antikörper wird verwendet zum Nachweis von p40 (p63 Delta) in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter p40 (p63 Delta) (AA 1-200) Antikörper (ABIN7864324)

Target: p40 (p63 Delta)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: P40-8225R

Produktdetails

Bindungsspezifität: AA 1-200

Verwendungszweck: Recombinant p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) Antibody

Spezifität: P63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. The p40 (clone P40/8225R) antibody recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.

Aufreinigung: 200ug/ml of Ab purified by Protein A Column.

Immunogen: Recombinant fragment (around aa1-200) of human TP63 protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Antigendetails

Target: p40 (p63 Delta)

Andere Bezeichnung: p40

Hintergrund:

deltaNp63, TP63

HeLa cells. Human prostate or lung tissue (IHC).

Molekulargewicht: 40kDa

Gen-ID: 8626, 137569

UniProt: Q9H3D4